Anthony Long, 15, from East Dulwich and Annabel Kramer, 14, from Catford are believed to have caught a train from London Euston to Manchester Piccadilly on Sunday. Police think the couple continued their journey to Scotland, and believe they arrived in Edinburgh yesterday afternoon.
CCTV images from Euston station show the missing couple carrying large rucksacks, suggesting they might be heading for an extended trip or maybe abroad.
Due to Antony and Annabel’s young age, their families and police officers are concerned for their safety and are appealing for the teenagers to make contact.
Anthony is described as white, 5ft 7ins in height and of a slim build. He was last seen wearing blue jeans, a black jacket and carrying a large red and blue rucksack. Annabel is white, 5ft 8ins in height and also of a slim build. She was last seen wearing black trousers and a red hooded top.
Anybody with any information should call Southwark police on 020 7232 6145 or contact Crimestoppers anonymously on 0800 555 111.